Dr. Jou, Yuh-Shan
PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression
Journal of Biomedical Science, Aug 02, 2021
Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the d ......
Dr. Chern, Yijuang
Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, Jul 28, 2021
Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of ......
Dr. Lee, Yungling Leo
Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood
Obesity Reviews, Jul 28, 2021
Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However ......
Dr. Liu, Fu-Tong
Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans
PNAS, Jul 27, 2021
Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory ......
Dr. Yang, Pan-Chyr
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer
Drug Discovery Today, Jul 26, 2021
Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of dru ......
Dr. Shen, Chen-Yang
Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: Applications to cardiovascular medicine.
J Adv Res., Jul 01, 2021
The human genome contains an enormous amount of informa-tion about human evolution, development, and medicine. To dis-cover the underlying g ......
Dr. Chern, Yijuang
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
Acta Neuropathologica Communications, Jun 25, 2021
Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s di ......
Dr. Tsai, Kevin
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing
Genes & Development, Jun 17, 2021
Previous work has demonstrated that the epitranscriptomic addition of m6A to viral transcripts can promote the replicati ......
Dr. Tang, Tang K.
Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position
Cells, Jun 09, 2021
Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain ......
Dr. Hu, Che-Ming (Jack)
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation
Advanced Materials, Jun 07, 2021
The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ......