2021 Highlights

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Dr. Shen , Chen-Yang
MiR-139 Modulates Cancer Stem Cell Function of Human Breast Cancer through Targeting CXCR4
Cancers May 25, 2021

  Simple Summary The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various cancer stem/progenitor cells via ...

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Dr. Yang , Shi-Bing
Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway
eLife May 21, 2021

    In the postnatal brain, neurogenesis occurs only within a few regions, such as the hippocampal sub-granular zone (SGZ). ...

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Dr. Cheng , Andrew Tai Ann
Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population
Translational Psychiatry May 20, 2021

    The search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irre ...

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Dr. Li , Chia-Wei
Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
American Journal of Cancer Research May 15, 2021

    The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Th ...

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Dr. Huang , Yi-Shuian
CPEB3-downregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice
Neuropsychopharmacology May 03, 2021

    Susceptibility or resilience to posttraumatic stress disorder (PTSD) depends on one's ability to appropriately adjus ...

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Dr. Hu , Yu-Feng
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088. May 01, 2021

    Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been ...

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Dr. Hsieh , Patrick Ching-Ho
Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer
Science Advances Apr 23, 2021

      The delivery of therapeutics through the circulatory system is one of the least arduous and less invasive inte ...

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Dr. Pan , Wen-Harn
Adequate protein intake in older adults in the context of frailty: cross-sectional results of the Nutrition and Health Survey in Taiwan 2014–2017
The American Journal of Clinical Nutrition Apr 13, 2021

    Background Emerging evidence suggests that a dietary protein intake higher than the current recommended dietary all ...

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Dr. Lim , Carmay
Metal Affinity/Selectivity of Monophosphate-Containing Signaling/Lipid Molecules
Journal of Chemical Theory and Computation Apr 04, 2021

    Monophosphate, an essential component of nucleic acids, as well as cell membranes and signaling molecules, is often boun ...

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Dr. Wang , Guey-Shin
CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure
FASEB journal Apr 03, 2021

    Vascular rarefaction due to impaired angiogenesis is associated with contractile dysfunction and the transition from com ...

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