2023 Highlights

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Dr. Chang , Ya-Jen
The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors
Experimental & Molecular Medicine Sep 11, 2023

A dysregulated type 2 immune response is one of the fundamental causes of allergic asthma. Although Th2 cells are undoubtedly central to the ...

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Dr. Suzuki , Jun
Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4
Nature Communications Sep 11, 2023

The "eat me" signal, phosphatidylserine is exposed on the surface of dying cells by phospholipid scrambling. Previously, we showed ...

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Dr. Tao , Mi-Hua
Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants
Molecular Therapy Sep 08, 2023

The ongoing evolution of SARS-CoV-2, resulting in the emergence of new variants that are resistant to existing vaccines and therapeutic anti ...

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Dr. Tarn , Woan-Yuh
Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency
Communications Biology Sep 05, 2023

A molecular and functional link between neurotrophin signaling and cerebellar foliation is lacking. Here we show that constitutive knockout ...

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Dr. Chen , Chih-Cheng
Probing the Effect of Acidosis on Tether-Mode Mechanotransduction of Proprioceptors
nternational Journal of Molecular Sciences Aug 14, 2023

      Proprioceptors are low-threshold mechanoreceptors involved in perceiving body position and strain bearing. How ...

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Dr. Lai , Shih-Lei (Ben)
Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration
eLife Jul 27, 2023

      Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays a ...

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Dr. Mou , Yun
Improvement of Gene Delivery by Minimal Bacteriophage Particles
ACS Nano Jul 19, 2023

      Direct delivery of therapeutic genes is a promising approach for treating cancers and other diseases. The curr ...

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Dr. Cheng , Sin-Jhong
Microbial metabolites regulate social novelty via CaMKII neurons in the BNST
Brain, Behavior, and Immunity Jun 29, 2023

      Social novelty is a cognitive process that is essential for animals to interact strategically with conspecific ...

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Dr. Lee , Yungling Leo
Neutrophil extracellular trap production and CCL4L2 expression influence corticosteroid response in asthma
Science Translational Medicine Jun 07, 2023

        The association between neutrophil extracellular traps (NETs) and response to inhaled corticosteroid ...

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Dr. Lin , Yi-Ling
Longitudinal neutralizing antibody responses after SARS-CoV-2 infection: A convalescent cohort study in Taiwan
Journal of Microbiology, Immunology and Infection Jun 07, 2023

        Background Understanding the neutralizing antibody (NAb) titer against COVID-19 over time is im ...

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