Dr. Roffler , Steve R.

High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation

Frontiers in Immunology Apr 09, 2018

How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the lar ......

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Dr. Jou , Yuh-Shan

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis

Nature cell biology Mar 28, 2018

Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is ne ......

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Dr. Lee , Te-Chang

Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2

Oncotarget Mar 23, 2018

Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may ge ......

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Dr. Tang , Tang K.

Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis

Nature Cell Biology Jan 15, 2018

Primary cilia play essential roles in signal transduction and development. The docking of preciliary vesicles at the distal appendages of a ......

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Dr. Jou , Yuh-Shan

EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma

Oncotarget Jan 11, 2018

Targeting tumor angiogenesis is a common strategy against human hepatocellular carcinoma (HCC). However, identification of molecular targets ......

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