Dr. Jou , Yuh-Shan PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression
Journal of Biomedical Science Aug 02, 2021Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the d ......
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Dr. Shen , Chen-Yang Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: Applications to cardiovascular medicine.
J Adv Res. Jul 01, 2021The human genome contains an enormous amount of informa-tion about human evolution, development, and medicine. To dis-cover the underlying g ......
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Dr. Tang , Tang K. Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position
Cells Jun 09, 2021Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain ......
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Dr. Shen , Chen-Yang MiR-139 Modulates Cancer Stem Cell Function of Human Breast Cancer through Targeting CXCR4
Cancers May 25, 2021Simple Summary The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various cancer stem/progenitor cells via ......
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Dr. Li , Chia-Wei Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
American Journal of Cancer Research May 15, 2021The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Th ......
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Dr. Yang , Pan-Chyr Vorinostat combined with brigatinib overcomes acquired resistance in EGFR-C797S-mutated lung cancer
Cancer Letters Mar 26, 2021The development of a new generation of tyrosine kinase inhibitors (TKIs) has improved the treatment response i ......
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Dr. Lee , Yu-Ru Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia
Nature Methods Mar 18, 2021The architecture of chromatin regulates eukaryotic cell states by controlling transcription factor access to s ......
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Dr. Suzuki , Jun Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane
Molecular Cell Mar 15, 2021Phospholipid scrambling in dying cells promotes phosphatidylserine exposure, a critical process for efferocyto ......
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Dr. Yang , Pan-Chyr PINK1-mediated inhibition of EGFR dimerization and activation impedes EGFR-driven lung tumorigenesis
Cancer Research Feb 09, 2021EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity is not fully unders ......
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Dr. Chau , Lee-Young Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation
Journal of Biomedical Science Jan 05, 2021Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early a ......
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