Dr. Wu , Jer-Yuarn Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans
American Journal of Human Genetics Jan 11, 2018Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ......
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Dr. Wu , Jer-Yuarn A genome-wide association study links small-vessel ischemic stroke to autophagy
Scientific Reports Nov 09, 2017Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ......
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Dr. Hu , Che-Ming (Jack) Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection
ACS Applied Materials & Interfaces Oct 31, 2017Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ......
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Dr. Hwang , Ming-Jing A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters
Scientific Reports Oct 27, 2017Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of pr ......
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Dr. Hsieh , Patrick Ching-Ho Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes
Theranostics Oct 13, 2017Rationale: Reducing cardiomyocyte death and enhancing their proliferation after myocardial infarction is perhaps the single largest challeng ......
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Dr. Chen , Chien-Chang Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus
Nature Communications Oct 10, 2017Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfu ......
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Dr. Yang , Ruey-Bing (Ray)FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation
Breast Cancer Research Oct 05, 2017Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fuco ......
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Dr. Yang , Ruey-Bing (Ray)Guanylyl cyclase‐G is an alarm pheromone receptor in mice
EMBO Journal Sep 28, 2017Many animals respond to threats by releasing alarm pheromones (APs) that warn conspecifics. In mice, detection of the AP 2‐sec‐butyl‐4,5‐dih ......
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Dr. Hsieh , Patrick Ching-Ho Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
Scientific Reports Sep 25, 2017Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R sign ......
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Dr. Wu , Jer-Yuarn A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol
Nature Communications Sep 12, 2017Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some health ......
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