Dr. Hsieh , Patrick Ching-Ho
Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme
ACS Nano Dec 11, 2018
The blood–brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and ......
detail
Dr. Yang , Ruey-Bing (Ray)
SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury
Biochimica et biophysica acta: molecular basis of disease Nov 07, 2018
We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a comp ......
detail
Dr. Chau , Lee-Young
Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene Oct 22, 2018
Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......
detail
Dr. Hu , Che-Ming (Jack)
725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria
Acta Biomaterialia Oct 11, 2018
Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......
detail
Dr. Hsieh , Patrick Ching-Ho
Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair
Circulation Oct 08, 2018
Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in ......
detail
Dr. Chang , Yi-Cheng
Genome-wide scan for circulating vascular
adhesion protein-1 levels: MACROD2 as a
potential transcriptional regulator of
adipogenesis
Journal of Diabetes Investigation Sep 01, 2018
Vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase highly expressed in mature adipocytes and released into the circu ......
detail
Dr. Chang , Yi-Cheng
Mitochondrial DNA associations with East Asian metabolic syndrome
Biochimica et Biophysica Acta (BBA) - Bioenergetics Sep 01, 2018
Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), as ......
detail
Dr. Shyue , Song-Kun
Deletion of caveolin‐1 attenuates LPS/GalN‐induced acute liver injury in mice
Journal of Cellular and Molecular Medicine Aug 22, 2018
Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin‐1 (Cav ......
detail
Dr. Chau , Lee-Young
Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Scientific Reports Jul 31, 2018
Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......
detail
Dr. Hsieh , Patrick Ching-Ho
The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling
Theranostics May 09, 2018
Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human ep ......
detail