Dr. Hsieh , Patrick Ching-Ho Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme
ACS Nano Dec 11, 2018The blood–brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and ......
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Dr. Yang , Ruey-Bing (Ray)SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury
Biochimica et biophysica acta: molecular basis of disease Nov 07, 2018We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a comp ......
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Dr. Chau , Lee-Young Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene Oct 22, 2018Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......
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Dr. Hu , Che-Ming (Jack) 725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria
Acta Biomaterialia Oct 11, 2018Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......
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Dr. Hsieh , Patrick Ching-Ho Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair
Circulation Oct 08, 2018Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in ......
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Dr. Chang , Yi-Cheng Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis
Journal of Diabetes Investigation Sep 01, 2018Vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase highly expressed in mature adipocytes and released into the circu ......
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Dr. Chang , Yi-Cheng Mitochondrial DNA associations with East Asian metabolic syndrome
Biochimica et Biophysica Acta (BBA) - Bioenergetics Sep 01, 2018Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), as ......
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Dr. Shyue , Song-Kun Deletion of caveolin‐1 attenuates LPS/GalN‐induced acute liver injury in mice
Journal of Cellular and Molecular Medicine Aug 22, 2018Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin‐1 (Cav ......
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Dr. Chau , Lee-Young Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Scientific Reports Jul 31, 2018Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......
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Dr. Hsieh , Patrick Ching-Ho The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling
Theranostics May 09, 2018Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human ep ......
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