Dr. Yang , Ruey-Bing (Ray)SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling
American Journal of Human Genetics Dec 11, 2020Summary Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of a small family of multifunctional cell surface-ancho ......
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Dr. Chau , Lee-Young Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......
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Dr. Chang , Yi-Cheng Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Nature Oct 14, 2020Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unkno ......
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Dr. Hsieh , Patrick Ching-Ho Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Journal of Biomedical Science Sep 04, 2020Abstract Background The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......
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Dr. Chang , Yi-Cheng Genome-wide association study for circulating fibroblast growth factor 21 and 23
Scientific reports Sep 03, 2020Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D ......
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Dr. Yang , Kai-Chien Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
Nature Communications Aug 26, 2020Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ......
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Dr. Chang , Yi-Cheng Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Nature Genetics Aug 24, 2020Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly us ......
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Dr. Chang , Yi-Cheng The Effects of Bariatric Surgery on Renal, Neurological, and Ophthalmic Complications in Patients with Type 2 Diabetes: the Taiwan Diabesity Study
Obesity surgery Jul 18, 2020Abstract Background: Bariatric surgery has been shown to improve glycemic control in patients with type 2 diabetes. However, less ......
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Dr. Hwang , Ming-Jing Detection and Classification of Cardiac Arrhythmias by a Challenge-Best Deep Learning Neural Network Model
iScience Mar 27, 2020Electrocardiograms (ECGs) are widely used to clinically detect cardiac arrhythmias (CAs). They are also being used to develop computer-assis ......
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Dr. Hu , Che-Ming (Jack) Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
Nano Letters Mar 17, 2020Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ......
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