Dr. Yang , Ruey-Bing (Ray)

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling

American Journal of Human Genetics Dec 11, 2020

Summary Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of a small family of multifunctional cell surface-ancho ......


Dr. Chau , Lee-Young

Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020

Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......


Dr. Chang , Yi-Cheng

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Nature Oct 14, 2020

Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unkno ......


Dr. Hsieh , Patrick Ching-Ho

Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank

Journal of Biomedical Science Sep 04, 2020

Abstract Background The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......


Dr. Chang , Yi-Cheng

Genome-wide association study for circulating fibroblast growth factor 21 and 23

Scientific reports Sep 03, 2020

Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D ......


Dr. Yang , Kai-Chien

Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Nature Communications Aug 26, 2020

Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ......


Dr. Chang , Yi-Cheng

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Nature Genetics Aug 24, 2020

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly us ......


Dr. Chang , Yi-Cheng

The Effects of Bariatric Surgery on Renal, Neurological, and Ophthalmic Complications in Patients with Type 2 Diabetes: the Taiwan Diabesity Study

Obesity surgery Jul 18, 2020

Abstract Background: Bariatric surgery has been shown to improve glycemic control in patients with type 2 diabetes. However, less ......


Dr. Hwang , Ming-Jing

Detection and Classification of Cardiac Arrhythmias by a Challenge-Best Deep Learning Neural Network Model

iScience Mar 27, 2020

Electrocardiograms (ECGs) are widely used to clinically detect cardiac arrhythmias (CAs). They are also being used to develop computer-assis ......


Dr. Hu , Che-Ming (Jack)

Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy

Nano Letters Mar 17, 2020

Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the r ......


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