Dr. Yang , Kai-Chien

Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling

Gut Dec 21, 2021

        Background and objectives:  Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......

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Dr. Cheng , Ching-Feng

The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning

Biomedicine & Pharmacotherapy Nov 25, 2021

    In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ......

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Dr. Hu , Yu-Feng

Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats

Nature Biomedical Engineering Nov 22, 2021

  Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......

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Dr. Chen , Chien-Chang

FAK regulates cardiomyocyte mitochondrial fission and function through Drp1

FEBS Journal Nov 05, 2021

    Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ......

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Dr. Shyue , Song-Kun

Atypical antipsychotics and CD36 pathway

Metabolism: clinical and experimental Aug 06, 2021

    Background Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from me ......

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Dr. Hsieh , Patrick Ching-Ho

Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation

Pharmaceutics Aug 03, 2021

Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site ......

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Dr. Pan , Wen-Harn

Adequate protein intake in older adults in the context of frailty: cross-sectional results of the Nutrition and Health Survey in Taiwan 2014–2017

The American Journal of Clinical Nutrition Aug 02, 2021

    Background Emerging evidence suggests that a dietary protein intake higher than the current recommended dietary all ......

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Dr. Hu , Che-Ming (Jack)

Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation

Advanced Materials Jun 07, 2021

    The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ......

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Dr. Hu , Yu-Feng

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis

Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088. May 01, 2021

    Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been ......

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Dr. Chang , Yi-Cheng

Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach

Frontiers in Endocrinology Apr 28, 2021

Reliable protein markers for pre-diabetes in humans are not clinically available. In order to identify novel and reliable protein markers fo ......

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