Dr. Yang , Kai-Chien
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
Gut Dec 21, 2021
Background and objectives:
Liver fibrosis (LF) occurs following chronic liver injuries. Cur ......
Dr. Cheng , Ching-Feng
The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
Biomedicine & Pharmacotherapy Nov 25, 2021
In this study, we investigated whether the activating transcription factor 3 (ATF3) inducer ST32db, a synthetic compound ......
Dr. Hu , Yu-Feng
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Nature Biomedical Engineering Nov 22, 2021
Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manip ......
Dr. Chen , Chien-Chang
FAK regulates cardiomyocyte mitochondrial fission and function through Drp1
FEBS Journal Nov 05, 2021
Loss of the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) in cardiomyocytes results in energy shortage a ......
Dr. Shyue , Song-Kun
Atypical antipsychotics and CD36 pathway
Metabolism: clinical and experimental Aug 06, 2021
Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from me ......
Dr. Hsieh , Patrick Ching-Ho
Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation
Pharmaceutics Aug 03, 2021
Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site ......
Dr. Pan , Wen-Harn
Adequate protein intake in older adults in the context of frailty: cross-sectional results of the Nutrition and Health Survey in Taiwan 2014–2017
The American Journal of Clinical Nutrition Aug 02, 2021
Emerging evidence suggests that a dietary protein intake higher than the current recommended dietary all ......
Dr. Hu , Che-Ming (Jack)
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation
Advanced Materials Jun 07, 2021
The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biom ......
Dr. Hu , Yu-Feng
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166088.
May 01, 2021
Point mutation in alcohol dehydrogenase 2 (ALDH2), ALDH2*2 results in decreased catalytic enzyme activity and has been ......
Dr. Chang , Yi-Cheng
Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Frontiers in Endocrinology
Apr 28, 2021
Reliable protein markers for pre-diabetes in humans are not clinically available. In order to identify novel and reliable protein markers fo ......