Dr. Hsieh , Patrick Ching-Ho

Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration

Circulation Nov 24, 2022

        BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adu ......

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Dr. Hsieh , Patrick Ching-Ho

Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

Theranostics Oct 17, 2022

        Background: The gut microbiota plays a vital role in maintaining tissue homeostasis and regulat ......

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Dr. Hsieh , Patrick Ching-Ho

Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine

Theranostics Oct 17, 2022

        Rationale: Gut microbiota plays a crucial role in cancer development and treatment. Studies sho ......

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Dr. Pan , Wen-Harn

Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank

Nutrients Sep 27, 2022

      Iron overnutrition has been implicated with a higher risk of developing metabolic and cardiovascular diseases, ......

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Dr. Hsieh , Patrick Ching-Ho

The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation

Biomaterials Sep 19, 2022

    We hypothesized that the host microbiome may influence foreign body responses following biomaterial implantation. To tes ......

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Dr. Yang , Kai-Chien

The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications

Journal of Biomedical Science Sep 02, 2022

      Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldw ......

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Dr. Yang , Ruey-Bing (Ray)

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia

Haematologica Aug 25, 2022

      A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia (AML) that offers an oppor ......

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Dr. Pan , Wen-Harn

Common and Ethnic-Specific Genetic Determinants of Hemoglobin Concentration between Taiwanese Han Chinese and European Whites: Findings from Comparative Two-Stage Genome-Wide Association Studies

Journal of Nutritional Biochemistry Aug 11, 2022

      Human iron nutrition is a result of interplays between genetic and environmental factors. However, there has b ......

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Dr. Pan , Wen-Harn

Healthy Taiwanese Eating Approach (TEA) toward Total Wellbeing and Healthy Longevity

Nutrients Jul 05, 2022

      A healthy dietary pattern review for Asian countries is scarce, which is crucial for guiding healthy eating. W ......

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Dr. Chen , Chien-Chang

Cav3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis

Journal of thrombosis and haemostasis Jul 01, 2022

      Background Cav3.2 is a T-type calcium channel that causes low-threshold exocytosis. T-type calcium channe ......

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