Dr. Shen , Chen-Yang

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.

The EMBO Journal Oct 30, 2008

The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasia-mutated (ATM)-checkpoint ......

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Dr. Yang , Pan-Chyr

Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma.

Am. J. Respir. Crit. Care Med. Sep 11, 2008

Rationale: Claudin-1(CLDN1), a key component of tight junction complexes, was down-regulated in human lung adenocarcinomas. Objectives: T ......

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Dr. Chau , Lee-Young

Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway.

Biochim Biophys Acta. May 21, 2008

The present study investigated the cellular mechanism underlying the degradation of heme oxygenase-1 (HO-1), an endoplasmic reticulum (ER ......

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Dr. Lin , Wen-chang

Designating eukaryotic orthology via processed transcription units.

Nucleic Acids Research Apr 29, 2008

Orthology is a widely used concept in comparative and evolutionary genomics. In addition to prokaryotic orthology, delineating eukaryotic ......

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Dr. Yang , Pan-Chyr

Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model.

Nano Lett. Feb 13, 2008

Carbon nanotubes are a nanomaterial that is extensively used in industry. The potential health risk of chronic carbon nanotubes exposure ......

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