Dr. Yang , Pan-Chyr

A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non–Small Cell Lung Cancer.

Clinical Cancer Research Nov 17, 2009

Metastasis is the main cause of mortality in non–small cell lung cancer (NSCLC) patients. Genes that can discriminate the invasion ......

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Dr. Tang , Tang K.

CPAP is a cell-cycle regulated protein that controls centriole length.

Nat Cell Biol. Jun 07, 2009

Centriole duplication involves the growing of a procentriole (progeny centriole) next to the proximal end of each pre-existing centriole ......

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Dr. Yang , Pan-Chyr

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.

Nature Cell Biology May 19, 2009

The tumour suppressor p53 is known to prevent cancer progression by inhibiting proliferation and inducing apoptosis of tumour cells. Slug ......

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Dr. Shieh , Sheau-Yann

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.

Mol. Cell. Biol. Mar 30, 2009

Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either elim ......

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Dr. Shieh , Sheau-Yann

Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

Oncogene Mar 30, 2009

Human checkpoint kinase 1 (CHK1) is an essential kinase required to preserve genome stability, and is activated by DNA replication blocka ......

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Dr. Roffler , Steve R.

Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses.

Clinical Cancer Research Mar 24, 2009

Tumor-localized activation of immune cells by membrane-tethered anti-CD3 antibodies (CD3L) is under investigation to treat poorly immunogeni ......

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Dr. Shieh , Sheau-Yann

The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.

Oncogene Jan 19, 2009

Cell cycle progression is monitored constantly to ensure faithful passage of genetic codes and genome stability. We have demonstrated pre ......

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