Dr. Wu , Cheng-Wen

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal Transdifferentiation.

Cancer Res. Dec 15, 2010

Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of ......

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Dr. Lin , Wen-chang

dbDNV: a resource of duplicated gene nucleotide variants in human genome.

Nucleic Acids Res Nov 21, 2010

Gene duplications are scattered widely throughout the human genome. A single-base difference located in nearly identical duplicated segments ......

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Dr. Jou , Yuh-Shan

IGRhCellID: integrated genomic resources of human cell lines for identification.

Nucleic Acids Research Nov 04, 2010

Cell line identification is emerging as an essential method for every cell line user in research community to avoid using misidentified cell ......

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Dr. Wu , Cheng-Wen

EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF.

Cancer Res. Nov 01, 2010

MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs co ......

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Dr. Jou , Yuh-Shan

Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma.

Hepatology Aug 31, 2010

Recurrent cancer genome aberrations are indicators of residing crucial cancer genes. Although recent advances in genomic technologies have l ......

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Dr. Shih , Hsiu-Ming

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

J Cell Biol. Jun 21, 2010

Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part ......

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Dr. Roffler , Steve R.

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling.

J Immunology Apr 30, 2010

Engagement of the TCR by antigenic peptides presented by the MHC activates specific T cells to control infections. Recent theoretical consid ......

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Dr. Shieh , Sheau-Yann

p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.

Oncogene Mar 01, 2010

The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of s ......

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