Dr. Jou , Yuh-Shan IGDB.NSCLC: integrated genomic database of non-small cell lung cancer.
Nucl. Acids Res Dec 01, 2011Lung cancer is the most common cause of cancer-related mortality with more than 1.4 million deaths per year worldwide. To search for signifi ......
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Dr. Shieh , Sheau-Yann Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis.
Oncogene Oct 24, 2011The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds ......
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Dr. Tang , Tang K. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.
EMBO Oct 21, 2011Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary m ......
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Dr. Jou , Yuh-Shan Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.
Oncogene Sep 26, 2011Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progression. In this s ......
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Dr. Yang , Pan-Chyr The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.
J Clin Invest. Aug 01, 2011Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if ......
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Dr. Shih , Hsiu-Ming Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
Molecular Cell May 08, 2011Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......
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Dr. Yang , Pan-Chyr SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.
Oncogene. Mar 28, 2011Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a secreted glycoprotein that is overexpressed in lung cancer tumor tissu ......
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Dr. Shen , Chen-Yang Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan.
N Engl J Med. Mar 24, 2011Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens–Johnson syndrome (SJS) and its related ......
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Dr. Yang , Pan-Chyr Enterovirus-Induced miR-141 Contributes to Shutoff of Host Protein Translation by Targeting the Translation Initiation Factor eIF4E.
Cell Host & Microbe Jan 20, 2011Viruses rely on the host translation machinery to complete their life cycles. Picornaviruses use an internal ribosome entry site to initiate ......
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