Dr. Jou , Yuh-Shan

IGDB.NSCLC: integrated genomic database of non-small cell lung cancer.

Nucl. Acids Res Dec 01, 2011

Lung cancer is the most common cause of cancer-related mortality with more than 1.4 million deaths per year worldwide. To search for signifi ......

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Dr. Shieh , Sheau-Yann

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis.

Oncogene Oct 24, 2011

The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds ......

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Dr. Tang , Tang K.

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

EMBO Oct 21, 2011

Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary m ......

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Dr. Jou , Yuh-Shan

Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.

Oncogene Sep 26, 2011

Common genetic alteration in cancer genomes is implicated for embracing an aberrant cancer gene participated in tumor progression. In this s ......

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Dr. Yang , Pan-Chyr

The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.

J Clin Invest. Aug 01, 2011

Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if ......

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Dr. Shih , Hsiu-Ming

Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.

Molecular Cell May 08, 2011

Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......

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Dr. Yang , Pan-Chyr

SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.

Oncogene. Mar 28, 2011

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a secreted glycoprotein that is overexpressed in lung cancer tumor tissu ......

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Dr. Yang , Pan-Chyr

Enterovirus-Induced miR-141 Contributes to Shutoff of Host Protein Translation by Targeting the Translation Initiation Factor eIF4E.

Cell Host & Microbe Jan 20, 2011

Viruses rely on the host translation machinery to complete their life cycles. Picornaviruses use an internal ribosome entry site to initiate ......

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