Dr. Tang , Tang K.

(invited News and Views article) Centriole biogenesis in multiciliated cells.

Nat Cell Biol. Dec 02, 2013

Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost sim ......


Dr. Shen , Chen-Yang

A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis.

Hum Mol Genet. Sep 22, 2013

To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199 961 single-nucleot ......


Dr. Tang , Tang K.

CEP120 interacts with CPAP and positively regulates centriole elongation.

JCB. Jul 15, 2013

Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein 4.1&ndas ......


Dr. Shih , Hsiu-Ming

HIC1 interacts with and modulates the activity of STAT3.

Cell Cycle. Jun 21, 2013

Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ......


Dr. Shieh , Sheau-Yann

Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.

PNAS Mar 26, 2013

B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic str ......


Dr. Tang , Tang K.

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.

EMBO J. Mar 19, 2013

Centrioles are cylindrical structures that are usually composed of nine triplets of microtubules (MTs) organized around a cartwheel-shaped s ......


Dr. Yang , Pan-Chyr

Extracellular delivery of modified oligonucleotide and superparamagnetic iron oxide nanoparticles from a degradable hydrogel triggered by tumor acidosis.

Biomaterials. Mar 08, 2013

Chemically modified antisense RNA oligonucleotides (antagomir) offer promise for cancer therapies but suffer from poor therapeutic effect af ......


Dr. Jou , Yuh-Shan

Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma.

Hepatology. Mar 04, 2013

Eukaryotic translation initiation factor 3 subunit I (eIF3I) with transforming capability is often overexpressed in human hepatocellular car ......


Dr. Shih , Hsiu-Ming

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.

EMBO J. Feb 08, 2013

While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ......


Dr. Chau , Lee-Young

Activator Protein-2α Mediates Carbon Monoxide-Induced Stromal Cell-Derived Factor-1α Expression and Vascularization in Ischemic Heart.

Arterioscler Thromb Vasc Biol. Feb 07, 2013

Increased cardiac stromal cell-derived factor-1α (SDF-1α) expression promotes neovascularization and myocardial repair after isc ......


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