Dr. Chau , Lee-Young

Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.

Oncogene. Jun 16, 2014

Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ......


Dr. Yang , Pan-Chyr

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.

Nat Commun. May 25, 2014

Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficul ......


Dr. Shieh , Sheau-Yann

Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.

J Biol Chem. Apr 24, 2014

Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its import ......


Dr. Hung , Shih Chieh

Hypoxic mesenchymal stem cells engraft and ameliorate limb ischaemia in allogeneic recipients.

Cardiovasc Res. Feb 01, 2014

Local injection of stem cells or endothelial progenitors directly into the ischaemic tissue remains an option for the management of arterial ......


Dr. Yang , Pan-Chyr

Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder.

Biomaterials. Jan 04, 2014

Early metastasis is one of the major causes of mortality among patient with lung cancer. The process of tumor metastasis involves a cascade ......


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