Dr. Yang , Pan-Chyr

Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation.

Am J Respir Crit Care Med. Nov 19, 2015

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Dr. Shieh , Sheau-Yann

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.

Nucl. Acids Res. Nov 03, 2015

Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......

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Dr. Yang , Pan-Chyr

MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.

Oncotarget. Nov 02, 2015

Melanoma differentiation-associated gene-9 (MDA-9)/Syntenin is a novel therapeutic target because it plays critical roles in cancer progress ......

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Dr. Yang , Pan-Chyr

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.

Oncotarget. Oct 19, 2015

Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondr ......

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Dr. Hung , Shih Chieh

Allo-transplantation of Mesenchymal Stem Cells Attenuates Hepatic Injury through IL1Ra Dependent Macrophage Switch in a Mouse Model of Liver Disease.

J Hepatol. Aug 11, 2015

Autologous transplantation of mesenchymal stem cells (MSCs) reduces concanavalin A (Con A)-induced hepatic injury in mice. However, the mech ......

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Dr. Roffler , Steve R.

Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies.

Mol Cancer Ther. Apr 07, 2015

Polyethylene glycol (PEG) is attached to many peptides, proteins, liposomes and nanoparticles to reduce their immunogenicity and improve the ......

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Dr. Yang , Pan-Chyr

CXCL10/IP-10 is a Biomarker and Mediator for Kawasaki Disease.

Nat Commun. Mar 05, 2015

Anticancer therapies are often compromised by nonspecific effects and challenged by tumour environments' inherent physicochemical and bi ......

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