Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation.

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.

Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......

MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.

Melanoma differentiation-associated gene-9 (MDA-9)/Syntenin is a novel therapeutic target because it plays critical roles in cancer progress ......

Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer.

Metastatic spread of cancer cells portends a poor prognosis and mortality for lung cancer patients. Hypoxia-inducible factor-1α (HIF-1 ......

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.

Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondr ......

Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.

OBJECTIVE: To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cu ......

Allo-transplantation of Mesenchymal Stem Cells Attenuates Hepatic Injury through IL1Ra Dependent Macrophage Switch in a Mouse Model of Liver Disease.

Autologous transplantation of mesenchymal stem cells (MSCs) reduces concanavalin A (Con A)-induced hepatic injury in mice. However, the mech ......

FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.

The association between breast cancer risk and genetic variants of fibroblast growth factor receptor 2 (FGFR2) has been identified and repea ......

Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies.

Polyethylene glycol (PEG) is attached to many peptides, proteins, liposomes and nanoparticles to reduce their immunogenicity and improve the ......

CXCL10/IP-10 is a Biomarker and Mediator for Kawasaki Disease.

Anticancer therapies are often compromised by nonspecific effects and challenged by tumour environments' inherent physicochemical and bi ......