Dr. Yang , Pan-Chyr Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
Nature communications Dec 22, 2016Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negativ ......
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Dr. Yang , Pan-Chyr Remote Control of Light-Triggered Virotherapy
ACS Nano Nov 07, 2016Clinical virotherapy has been successfully approved for use in cancer treatment by the U.S. Food and Drug Administration; however, a number ......
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Dr. Chen , Joanne Jeou-Yuan Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner
Oncogene Nov 07, 2016Tumor microenvironment (TME) plays an active role in promoting tumor progression. To further understand the communication between TME and tu ......
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Dr. Roffler , Steve R. Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals
Analytical chemistry Oct 11, 2016Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeu ......
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Dr. Hung , Shih Chieh Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
Nature Communications Jun 16, 2016Targeting tumour-initiating cells (TICs) would lead to new therapies to cure cancer. We previously demonstrated that TICs have the capacity ......
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Dr. Li , Ling-Hui Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression
Oncotarget Jun 13, 2016Development of colorectal cancer (CRC) involves sequential transformation of normal mucosal tissues into benign adenomas and then adenomas i ......
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Dr. Tang , Tang K. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.
Cell Reports Mar 15, 2016CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that ......
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Dr. Shen , Chen-Yang MicroRNA-30a increases tight junction protein expression to suppress the epithelial-mesenchymal transition and metastasis by targeting Slug in breast cancer.
Oncotarget Feb 24, 2016The epithelial-to-mesenchymal (EMT) transition is a prerequisite for conferring metastatic potential during tumor progression. microRNA-30a ......
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Dr. Roffler , Steve R. Engineering Chimeric Receptors to Investigate the Size and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells.
ACS Nano. Jan 07, 2016Attachment of ligands to the surface of nanoparticles (NPs) is an attractive approach to target specific cells and increase intracellular de ......
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