Dr. Yang , Pan-Chyr

Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Nature communications Dec 22, 2016

Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negativ ......

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Dr. Yang , Pan-Chyr

Remote Control of Light-Triggered Virotherapy

ACS Nano Nov 07, 2016

Clinical virotherapy has been successfully approved for use in cancer treatment by the U.S. Food and Drug Administration; however, a number ......

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Dr. Chen , Joanne Jeou-Yuan

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner

Oncogene Nov 07, 2016

Tumor microenvironment (TME) plays an active role in promoting tumor progression. To further understand the communication between TME and tu ......

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Dr. Roffler , Steve R.

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Analytical chemistry Oct 11, 2016

Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeu ......

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Dr. Hung , Shih Chieh

Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Nature Communications Jun 16, 2016

Targeting tumour-initiating cells (TICs) would lead to new therapies to cure cancer. We previously demonstrated that TICs have the capacity ......

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Dr. Tang , Tang K.

Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.

Cell Reports Mar 15, 2016

CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that ......

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Dr. Roffler , Steve R.

Engineering Chimeric Receptors to Investigate the Size and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells.

ACS Nano. Jan 07, 2016

Attachment of ligands to the surface of nanoparticles (NPs) is an attractive approach to target specific cells and increase intracellular de ......

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