Dr. Lee , Te-Chang

A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer

Neoplasia Dec 13, 2017

Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ......


Dr. Shih , Hsiu-Ming

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

Scientific Reports Dec 12, 2017

The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......


Dr. Jou , Yuh-Shan

Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis

Oncotarget Sep 08, 2017

Cellular metabolism of cancer cell is generally recognized to provide energy for facilitating tumor growth, but little is known about the ab ......


Dr. Chau , Lee-Young

Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness

Oncogene Aug 28, 2017

Overexpression of heme oxygenase-1 (HO-1), an endoplasmic reticulum-anchored enzyme, is observed in many cancers. HO-1 nuclear translocation ......


Dr. Yang , Pan-Chyr

A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

Molecular Therapy- Nucleic Acids Aug 15, 2017

Introduction The concept of immune checkpoint blockade has revolutionized anti-cancer strategies in nearly all cancer fields.1 Monoclonal ......


Dr. Tang , Tang K.

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

Nature Communications Aug 15, 2017

Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that ......


Dr. Lin , Wen-chang

A Comprehensive Analysis of Transcript-Supported De Novo Genes in Saccharomyces sensu stricto Yeasts

Molecular Biology and Evolution Jul 24, 2017

Novel genes arising from random DNA sequences (de novo genes) have been suggested to be widespread in the genomes of different organisms. Ho ......


Dr. Roffler , Steve R.

The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering

Frontiers in Immunology Jul 10, 2017

T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The inte ......


Dr. Roffler , Steve R.

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

Nature Communications Jun 08, 2017

Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal ......


Dr. Lin , Wen-chang

Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer

Oncotarget Apr 07, 2017

Many reports have implicated that microRNAs involve in cancer development and progression, such as miR-155 in breast cancers and miR-196 in ......


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