Dr. Lee , Te-Chang Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer
Cancers Oct 22, 2018Aberrant DNA methylation is a potential mechanism underlying the development of colorectal cancer (CRC). Thus, identification of prognostic ......
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Dr. Chau , Lee-Young Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
Oncogene Oct 22, 2018Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......
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Dr. Shieh , Sheau-Yann CHK2-mediated regulation of PARP1 in oxidative DNA damage response
Oncogene Sep 25, 2018Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation ......
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Dr. Shen , Chen-Yang Increased Cellular Levels of MicroRNA-9 and MicroRNA-221 Correlate with Cancer Stemness and Predict Poor Outcome in Human Breast Cancer
Cellular Physiology and Biochemistry Aug 15, 2018Background /Aims: Recent studies of microRNA (miRNA) involvement in tumorigenesis have indicated the critical role of these non-coding small ......
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Dr. Chau , Lee-Young Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Scientific Reports Jul 31, 2018Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......
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Dr. Wu , Cheng-Wen Upregulation of E3 ubiquitin ligase CBLC enhances EGFR dysregulation and signaling in lung adenocarcinoma
Cancer Research Jun 26, 2018CBLC (CBL proto-oncogene c) belongs to the CBL protein family which has E3 ubiquitin ligase activity towards activated receptor tyrosine kin ......
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Dr. Roffler , Steve R. Transient AID expression for in situ mutagenesis with improved cellular fitness
Scientific Reports Jun 20, 2018Activation induced cytidine deaminase (AID) in germinal center B cells introduces somatic DNA mutations in transcribed immunoglobulin genes ......
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Dr. Roffler , Steve R. Reversible glycosidic switch for secure delivery of molecular nanocargos
Nature Communications May 10, 2018Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which ......
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Dr. Shieh , Sheau-Yann Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
PNAS May 07, 2018Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......
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Dr. Shen , Chen-Yang SUMOylation of XRCC1 activated by poly(ADP-ribosyl)ation regulates DNA repair
Human Molecular Genetics Apr 16, 2018XRCC1 is an essential scaffold protein for base excision repair (BER) and helps to maintain genomic stability. XRCC1 has been indicated as a ......
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