Dr. Lee , Te-Chang

Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer

Cancers Oct 22, 2018

Aberrant DNA methylation is a potential mechanism underlying the development of colorectal cancer (CRC). Thus, identification of prognostic ......

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Dr. Chau , Lee-Young

Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation

Oncogene Oct 22, 2018

Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......

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Dr. Shieh , Sheau-Yann

CHK2-mediated regulation of PARP1 in oxidative DNA damage response

Oncogene Sep 25, 2018

Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation ......

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Dr. Chau , Lee-Young

Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics

Scientific Reports Jul 31, 2018

Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......

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Dr. Wu , Cheng-Wen

Upregulation of E3 ubiquitin ligase CBLC enhances EGFR dysregulation and signaling in lung adenocarcinoma

Cancer Research Jun 26, 2018

CBLC (CBL proto-oncogene c) belongs to the CBL protein family which has E3 ubiquitin ligase activity towards activated receptor tyrosine kin ......

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Dr. Roffler , Steve R.

Transient AID expression for in situ mutagenesis with improved cellular fitness

Scientific Reports Jun 20, 2018

Activation induced cytidine deaminase (AID) in germinal center B cells introduces somatic DNA mutations in transcribed immunoglobulin genes ......

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Dr. Roffler , Steve R.

Reversible glycosidic switch for secure delivery of molecular nanocargos

Nature Communications May 10, 2018

Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which ......

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Dr. Shieh , Sheau-Yann

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

PNAS May 07, 2018

Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......

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Dr. Roffler , Steve R.

High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation

Frontiers in Immunology Apr 09, 2018

How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the lar ......

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Dr. Jou , Yuh-Shan

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis

Nature cell biology Mar 28, 2018

Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is ne ......

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