Dr. Roffler , Steve R.

Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice

Pharmaceutics Dec 21, 2019

Pre-existing antibodies that bind polyethylene glycol are present in about 40% of healthy individuals. It is currently unknown if pre-existi ......

detail

Dr. Jou , Yuh-Shan

Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Nucleic Acids Research Dec 19, 2019

Precise noncoding RNA (ncRNA)-based network prediction is necessary to reveal ncRNA functions and pathological mechanisms. Here, we establis ......

detail

Dr. Jou , Yuh-Shan

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Nature Communications Dec 16, 2019

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation h ......

detail

Dr. Lin , Wen-chang

Overlapping protein-coding genes in human genome and their coincidental expression in tissues

Scientific Reports Sep 16, 2019

The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understandin ......

detail

Dr. Yang , Pan-Chyr

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin

European Journal of Medicinal Chemistry Aug 02, 2019

Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we ......

detail

Dr. Jou , Yuh-Shan

A New Switch for TGFβ in Cancer

Cancer Research Jul 12, 2019

The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pa ......

detail

Dr. Roffler , Steve R.

Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

Biomaterials Science Jun 28, 2019

For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the ......

detail

Dr. Tang , Tang K.

CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis

Scientific Reports Apr 15, 2019

Centrosomal protein 120 (CEP120) was originally identified as a daughter centriole-enriched protein that participates in centriole elongatio ......

detail

Dr. Yang , Pan-Chyr

A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure

Theranostics Feb 28, 2019

Rationale: The TNF-α pathway plays as a double-edged sword that simultaneously regulates cell apoptosis and proliferation. The dysregu ......

detail

Dr. Lee , Te-Chang

IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling

oncogene Jan 09, 2019

IFIT1 and IFIT3 are abundant products of interferon-stimulating genes. While the importance of IFIT1 and IFIT3 in the prognosis of cancer ha ......

detail

Record 1 to 10, total of 10 records