Dr. Shen , Chen-Yang
Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People
Molecular Biology and Evolution Dec 18, 2020
Abstract
The Taiwanese people are composed of diverse indigenous populations and the Taiwanese Han. About 95% of the Taiwanese identify ......
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Dr. Shieh , Sheau-Yann
Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease Dec 11, 2020
Abstract
B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ......
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Dr. Yang , Pan-Chyr
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
EMBO Molecular Medicine Nov 30, 2020
Abstract
To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a hum ......
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Dr. Lee , Te-Chang
SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
Cancers Nov 26, 2020
Simple Summary
IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ......
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Dr. Yang , Pan-Chyr
Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
Journal for ImmunoTherapy of Cancer Nov 26, 2020
Abstract
Background: The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) ha ......
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Dr. Chau , Lee-Young
Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020
Abstract
Objective:
Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......
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Dr. Lin , Wen-chang
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports Oct 01, 2020
Abstract
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......
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Dr. Yang , Pan-Chyr
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression
Cell Jul 09, 2020
Summary
Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ......
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Dr. Lee , Te-Chang
Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
Eur J Med Chem Jun 23, 2020
Abstract
A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......
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Dr. Jou , Yuh-Shan
PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
Cells Jun 18, 2020
Abstract
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......
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