Dr. Shieh , Sheau-Yann

Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation

Cell Death & Disease Dec 11, 2020

Abstract B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ......

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Dr. Yang , Pan-Chyr

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

EMBO Molecular Medicine Nov 30, 2020

Abstract To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a hum ......

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Dr. Lee , Te-Chang

SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells

Cancers Nov 26, 2020

Simple Summary IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ......

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Dr. Yang , Pan-Chyr

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy

Journal for ImmunoTherapy of Cancer Nov 26, 2020

Abstract Background:  The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) ha ......

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Dr. Chau , Lee-Young

Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020

Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......

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Dr. Lin , Wen-chang

Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset

Scientific Reports Oct 01, 2020

Abstract With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......

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Dr. Yang , Pan-Chyr

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

Cell Jul 09, 2020

Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ......

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Dr. Lee , Te-Chang

Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives

Eur J Med Chem Jun 23, 2020

Abstract A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......

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Dr. Jou , Yuh-Shan

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells Jun 18, 2020

Abstract Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......

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Dr. Yang , Pan-Chyr

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer

Journal of Controlled Release Jun 01, 2020

Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......

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