Dr. Shieh , Sheau-Yann Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation
Cell Death & Disease Dec 11, 2020Abstract B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53 ......
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Dr. Yang , Pan-Chyr Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
EMBO Molecular Medicine Nov 30, 2020Abstract To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a hum ......
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Dr. Lee , Te-Chang SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
Cancers Nov 26, 2020Simple Summary IFIT2 depletion is associated with increased epithelial-mesenchymal transition and metastasis. The main aim of our s ......
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Dr. Yang , Pan-Chyr Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
Journal for ImmunoTherapy of Cancer Nov 26, 2020Abstract Background: The immune checkpoint blockade (ICB) targeting programmed cell death-1 (PD-1) and its ligand (PD-L1) ha ......
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Dr. Chau , Lee-Young Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Arteriosclerosis, Thrombosis, and Vascular Biology Nov 05, 2020Abstract Objective: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and signi ......
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Dr. Lin , Wen-chang Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports Oct 01, 2020Abstract With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......
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Dr. Yang , Pan-Chyr Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression
Cell Jul 09, 2020Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ......
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Dr. Lee , Te-Chang Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
Eur J Med Chem Jun 23, 2020Abstract A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates an ......
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Dr. Jou , Yuh-Shan PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
Cells Jun 18, 2020Abstract Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associat ......
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Dr. Yang , Pan-Chyr Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer
Journal of Controlled Release Jun 01, 2020Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......
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