Dr. Lee , Yu-Ru

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models

Journal of Clinical Investigation Dec 15, 2021

Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ......

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Dr. Roffler , Steve R.

Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice

Biomedicine & Pharmacotherapy Dec 06, 2021

    Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......

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Dr. Li , Chia-Wei

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

EBioMedicine Nov 25, 2021

    Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......

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Dr. Chen , Shih-Yu

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2

Journal of Clinical Investigation Nov 01, 2021

To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to ......

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Dr. Tang , Tang K.

CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum

Genes & Development Oct 28, 2021

    Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypo ......

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Dr. Li , Chia-Wei

Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis

American Journal of Cancer Research Oct 15, 2021

SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ......

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Dr. Roffler , Steve R.

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

ACS Nano Sep 02, 2021

    Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......

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Dr. Lee , Te-Chang

Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links

Journal of Medicinal Chemistry Aug 30, 2021

    Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatm ......

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Dr. Shen , Chen-Yang

Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study

American Journal of Cancer Research Aug 30, 2021

The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of t ......

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Dr. Mou , Yun

Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment

ACS Synthetic Biology Aug 03, 2021

    Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor acti ......

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