Dr. Lee , Yu-Ru WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models
Journal of Clinical Investigation Dec 15, 2021Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysf ......
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Dr. Roffler , Steve R. Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice
Biomedicine & Pharmacotherapy Dec 06, 2021Antibodies that bind polyethylene glycol (PEG) can be induced by pegylated biomolecules and also exist in a si ......
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Dr. Li , Chia-Wei Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro
EBioMedicine Nov 25, 2021Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and ......
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Dr. Chen , Shih-Yu NK cell receptor and ligand composition influences the clearance of SARS-CoV-2
Journal of Clinical Investigation Nov 01, 2021To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to ......
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Dr. Tang , Tang K. CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum
Genes & Development Oct 28, 2021Joubert syndrome (JS) is a recessive ciliopathy in which all affected individuals have congenital cerebellar vermis hypo ......
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Dr. Li , Chia-Wei Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis
American Journal of Cancer Research Oct 15, 2021SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). ......
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Dr. Roffler , Steve R. Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies
ACS Nano Sep 02, 2021Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, n ......
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Dr. Lee , Te-Chang Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links
Journal of Medicinal Chemistry Aug 30, 2021Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatm ......
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Dr. Shen , Chen-Yang Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study
American Journal of Cancer Research Aug 30, 2021The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of t ......
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Dr. Mou , Yun Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment
ACS Synthetic Biology Aug 03, 2021Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor acti ......
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