Dr. Yang , Pan-Chyr

Vorinostat combined with brigatinib overcomes acquired resistance in EGFR-C797S-mutated lung cancer

Cancer Letters Mar 26, 2021

    Abstract The development of a new generation of tyrosine kinase inhibitors (TKIs) has improved the treatment respon ......

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Dr. Suzuki , Jun

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

Molecular Cell Mar 15, 2021

Summary Phospholipid scrambling in dying cells promotes phosphatidylserine exposure, a critical process for efferocytosis. We ......

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Dr. Yang , Pan-Chyr

PINK1-mediated inhibition of EGFR dimerization and activation impedes EGFR-driven lung tumorigenesis

Cancer Research Feb 09, 2021

  EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity is not fully unders ......

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Dr. Chau , Lee-Young

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Journal of Biomedical Science Jan 05, 2021

Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early a ......

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