Student's Publication

  • Chia Hsiang Chang 張家祥 (Advisor: Dr. Jin-Wu Tsai)
    Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O. Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation. Dev Cell. 2019 Jan 28;48(2):184-199.e5. doi: 10.1016/j.devcel.2018.12.017. PubMed PMID: 30695697.
  • Oi Kuan Choong 鍾愛君 (Advisor: Dr. Patrick C.H. Hsieh)
    Choong OK, Chen CY, Zhang J, Lin JH, Lin PJ, Ruan SC, Kamp TJ, Hsieh PCH. Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction. Theranostics. 2019 Aug 21;9(22):6550-6567. doi: 10.7150/thno.35218. eCollection 2019. PubMed PMID: 31588235; PubMed Central PMCID: PMC6771230.
  • Hsiang-Chi Huang 黃湘琦 (Advisor: Dr. Reiji Kannagi)
    Huang HC, Chao CC, Wu PH, Chung HY, Lee HY, Suen CS, Hwang MJ, Cai BH, Kannagi R. Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers. Biochim Biophys Acta Gene Regul Mech. 2019 Feb;1862(2):173-183. doi: 10.1016/j.bbagrm.2019.01.002. Epub 2019 Feb 1. PubMed PMID: 30716533.
  • Meng Syuan Lin 林孟璇 (Advisor: Dr. Yijuang Chern)
    Lin MS, Liao PY, Chen HM, Chang CP, Chen SK, Chern Y. Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment. J Neurosci. 2019 Feb 20;39(8):1505-1524. doi: 10.1523/JNEUROSCI.0571-18.2018. Epub 2018 Dec 26. PubMed PMID: 30587542; PubMed Central PMCID: PMC6381252.
  • Vijaya Kumar Pidugu 韋加亞 (Advisor: Dr. Te-Chang Lee)
    Pidugu VK, Wu MM, Yen AH, Pidugu HB, Chang KW, Liu CJ, Lee TC. IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling. Oncogene. 2019 Apr;38(17):3232-3247. doi: 10.1038/s41388-018-0662-9. Epub 2019 Jan 9. PubMed PMID: 30626937.
  • Jian Jing Siew 蕭建靖 (Advisor: Dr. Yijuang Chern)
    Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, Lin CH, Liu FT, Chern Y. Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun. 2019 Aug 2;10(1):3473. doi: 10.1038/s41467-019-11441-0. PubMed PMID: 31375685; PubMed Central PMCID: PMC6677843.
  • Yi-Hsiu Wu 吳逸修 (Advisor: Dr. Ya-Jen Chang)
    Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, Chang YJ. Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy. 2019 Oct 17. doi: 10.1111/all.14091. [Epub ahead of print] PubMed PMID: 31622507.
  • Doaa Glal Mohamed Abozeid 高荳 (Advisor: Dr. Jr-Wen Shui)
    Glal D, Sudhakar JN, Lu HH, Liu MC, Chiang HY, Liu YC, Cheng CF, Shui JW. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018 Nov 5;9:2522. doi: 10.3389/fimmu.2018.02522. eCollection 2018. PubMed PMID: 30455690; PubMed Central PMCID: PMC6230592.
  • Chih-Chan Lee 李志展 (Advisor: Dr. Muh-Hwa Yang)
    Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH. (2018) Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun. 9(1):3763. doi: 10.1038/s41467-018-06268-0. [PDF]
  • Yu-Chia Chuang 莊育嘉 (Advisor: Dr. Chih-Cheng Chen)
    Chuang YC, Lee CH, Sun WH, Chen CC. (2018) Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1716470115. Epub 2018 Aug 20. [PDF]
  • Christina Li Ping Thio 張麗萍 (Advisor: Dr. Ya-Jen Chang)
    Thio CL, Chi PY, Lai AC, Chang YJ. (2018) Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. J Allergy Clin Immunol. pii: S0091-6749(18)30325-7. doi: 10.1016/j.jaci.2018.02.032. [PDF]
  • Talal Salem Al-Qaisi 安奎道 (Advisor: Dr. Steve R. Roffler)
    Al-Qaisi TS, Su YC, Roffler SR. (2018) Transient AID expression for in situ mutagenesis with improved cellular fitness. Sci Rep. 8(1):9413. doi: 10.1038/s41598-018-27717-2. [PDF]
  • Dhananjaya D 何安亞 (Advisor: Dr. Woan-Yuh Tarn)
    D D, Hung KY, Tarn WY. (2018) RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. Mol Cell Biol. 38(12). pii: e00007-18. doi: 10.1128/MCB.00007-18. [PDF]
  • Pierre-Alain Burnouf 白宸睿 (Advisor: Dr. Steve R. Roffler)
    Burnouf PA, Leu YL, Su YC, Wu K, Lin WC, Roffler SR. (2018) Reversible glycosidic switch for secure delivery of molecular nanocargos. Nat Commun. 9(1):1843. doi: 10.1038/s41467-018-04225-5. [PDF]
  • Mohammad Ameen Alaghbar 歐默漢 (Advisor: Dr. Steve R. Roffler)
    Al-Aghbar MA, Chu YS, Chen BM, Roffler SR. (2018) High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation. Front Immunol. 9:713. doi: 10.3389/fimmu.2018.00713. [PDF]
  • Wen-Hsin Lu 呂文心 (Advisor: Dr. Yi-Shuian Huang)
    Lu WH, Yeh NH, Huang YS. (2017) CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory. Cell Rep. 21(7):1783-1794. doi: 10.1016/j.celrep.2017.10.073. [PDF]
  • Gansukh Choijilsuren 札蘇光士 (Advisor: Dr. Chiaho Shih)
    Choijilsuren G, Jhou RS, Chou SF, Chang CJ, Yang HI, Chen YY, Chuang WL, Yu ML, Shih C. (2017) Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus. Sci Rep. 7(1):14461. doi: 10.1038/s41598-017-14573-9. [PDF]
  • Ya-Lin Lin 林雅琳 (Advisor: Dr. Fang Liao)
    Lin YL, Ip PP, Liao F. (2017) CCR6 Deficiency Impairs IgA Production and Dysregulates Antimicrobial Peptide Production, Altering the Intestinal Flora. Front Immunol. 8:805. doi: 10.3389/fimmu.2017.00805. [PDF]
  • Mohammad Ameen Alaghbar 歐默漢 (Advisor: Dr. Steve R. Roffler)
    Chen BM*, Al-Aghbar MA*, Lee CH, Chang TC, Su YC, Li YC, Chang SE, Chen CC, Chung TH, Liao YC, Lee CH, Roffler SR. (2017) The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering. Front Immunol. 8:793. doi: 10.3389/fimmu.2017.00793. [PDF] (*contributed equally)
  • Chia-Chen Lu 呂佳臻 (Advisor: Dr. Woan-Yuh Tarn)
    Lu CC, Lee CC, Tseng CT, Tarn WY (2017) Y14 governs p53 expression and modulates DNA damage sensitivity. Sci Rep. 7:45558. doi: 10.1038/srep45558 [PDF]
  • Jui-Hao Lee 李睿豪 (Advisor: Dr. Chi-Hung Lin)
    Lee JH, Hsieh CF, Liu HW, Chen CY, Wu SC, Chen TW, Hsu CS, Liao YH, Yang CY, Shyu JF, Fischer WB, Lin CH (2017) Lipid raft-associated stomatin enhances cell fusion. FASEB J. 31(1):47-59. doi: 10.1096/fj.201600643R [PDF]
  • Pei-Yi Su 蘇倍儀 (Advisor: Dr. Chiaho Shih)
    Su PY, Yang CJ, Chu TH, Chang CH, Chiang C, Tang FM, Lee CY, Shih C (2016) HBV maintains electrostatic homeostasis by modulating negative charges from phosphoserine and encapsidated nucleic acids. Sci Rep. 6:38959. doi: 10.1038/srep38959 [PDF]
  • Marilyn Rimando 雷瑪琳 (Advisor: Dr. Oscar Kuang-Sheng Lee)
    Rimando MG, Wu HH, Liu YA, Lee CW, Kuo SW, Lo YP, Tseng KF, Liu YS, Lee OK (2016) Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs). Sci Rep. 6:37371. doi: 10.1038/srep37371 [PDF]
  • An-Ting Liou 劉安庭 (Advisor: Dr. Chiaho Shih)
    Liou AT, Wu SY, Liao CC, Chang YS, Chang CS, Shih C (2016) A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71. Sci Rep. 6:31151. doi: 10.1038/srep31151 [PDF]
  • Nana Hsiang-Hua Wang 王襄華 (Advisor: Dr. Yuan-Tsong Chen)
    Wang NH, Chen SJ, Yang CF, Chen HW, Chuang HP, Lu YH, Chen CH, Wu JY, Niu DM, Chen YT (2016) Homozygosity Mapping and Whole-Genome Sequencing Links a Missense Mutation in POMGNT1 to Autosomal Recessive Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 57(8):3601-9. doi: 10.1167/iovs.16-19463 [PDF]
  • Tzu-Po Chuang 莊諮博 (Advisor: Dr. Yuan-Tsong Chen & Dr. Ling-Hui Li)
    Chuang TP, Wang JY, Jao SW, Wu CC, Chen JH, Hsiao KH, Lin CY, Chen SH, Su SY, Chen YJ, Chen YT, Wu DC, Li LH (2016) Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Oncotarget. doi: 10.18632/oncotarget.9960 [PDF]
  • Wei-Sheng Sun 孫維聲 (Advisor: Dr. Wan-Jr Syu)
    Sun WS, Chen JW, Wu YC, Tsai HY, Kuo YL, Syu WJ (2016) Expression Regulation of Polycistronic lee3 Genes of Enterohaemorrhagic Escherichia coli. PLoS One. 11(5):e0155578 [PDF]
  • Ching-Pang Chang 張敬邦 (Advisor: Dr. Yijuang Chern)
    Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC, Chern Y (2016) Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci Rep. 6:22529 [PDF]
  • Pierre-Alain Burnouf 白宸睿 (Advisor: Dr. Steve R. Roffler)
    Huang WC, Burnouf PA, Su YC, Chen BM, Chuang KH, Lee CW, Wei PK, Cheng TL, Roffler SR (2016) Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells. ACS Nano. 10(1):648-62 [PDF]
  • Chia-Sui Sun 孫嘉穗 (Advisor: Dr. Yijuang Chern and Dr. Joseph Jen-Tse Huang)
    Sun CS, Lee CC, Li YN, Yang SY, Lin CH, Chang YC, Liu PF, He RY, Wang CH, Chen W, Chern Y, Huang JJ. (2015) Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect. Sci Rep. 5:14992. [PDF]
  • Ai-Chung Mar 馬璦中 (Advisor: Dr. Te-Chang Lee)
    Mar AC, Chu CH, Lee HJ, Chien CW, Cheng JJ, Yang SH, Jiang JK, Lee TC. (2015) Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. J Biol Chem. 290(36):22212-24. [PDF]
  • Ying-Chi Chao 趙英淇 (Advisor: Dr. Ruey-Bing Yang)
    Chao YC, Chen CC, Lin YC, Breer H, Fleischer J, Yang RB. (2015) Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures. EMBO J. 34(3): 294-306. [PDF]
  • Pei-Ying Lin 林佩瑩 (Advisor: Dr. Pan-Cher Yang and Dr. Konan Peck)
    Lin PY, Chang SN, Hsiao TH, Huang BT, Lin CH, Yang PC. (2015) Association Between Parkinson Disease and Risk of Cancer in Taiwan. JAMA Oncol. doi:10.1001/jamaoncol.2015.1752 [PDF]
  • Hsin-Yi Tung 童馨儀 (Advisor: Dr. Steve R. Roffler)
    Tung HY, Su YC, Chen BM, Burnouf PA, Huang WC, Chuang KH, Yan YT, Cheng TL, Roffler SR. (2015) Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies. Mol Cancer Ther. 14(6): 1317–26. [PDF]
  • Yogy Simanjuntak 史曼均 (Advisor: Dr. Pang-Hsien Tu and Dr. Yijuang Chern)
    Shen WC, Li HY, Chen GC, Chern Y, Tu PH. (2015) Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism. Autophagy 11(4):685-700. [PDF]
  • Wen-Chuan Shen 沈文荃 (Advisor: Dr. Pang-Hsien Tu and Dr. Yijuang Chern)
    Shen WC, Li HY, Chen GC, Chern Y, Tu PH. (2015) Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism. Autophagy 11(4):685-700. [PDF]
  • Irfan Naseem Bandey 潘爾納 (Advisor: Dr. Pang-Hsien Tu)
    Bandey I, Chiou SH, Huang AP, Tsai JC, Tu PH (2015) Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. Oncogene 34(14):1853-64. [PDF]
  • Chia-Sui Sun 孫嘉穗 (Advisor: Dr. Yijuang Chern and Dr. Joseph Jen-Tse Huang)
    Sun CS, Wang CY Chen BP, He RY, Liu GC, Wang CH, Chen W, Chern Y, Huang JJ. (2014) The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity. PLoS ONE 9(8): e103644. [PDF]
  • Wei-Ting Chen 陳暐婷 (Advisor: Dr. Irene Han-Juo Cheng)
    Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. (2014) G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca2+ Accumulation. Mol Neurobiol. DOI:10.1007/s12035-014-8969-1. [PDF]
  • Kai-Ting Chen 陳凱婷 (Advisor: Dr. Hsei-Wei Wang)
    Chen KT, Pernelle K, Tsai YH, Wu YH, Hsieh JY, Liao KH, Guguen-Guillouzo C, Wang HW. (2014) Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α. J Hepatol. 61(6):1276-86. [PDF]
  • Cheng-Fen Tu 凃瀞芬 (Advisor: Dr. Ruey-Bing Ray Yang)
    Tu CF, Tsao KC, Lee SJ, Yang RB. (2014) SCUBE3 (Signal Peptide-CUB-EGF Domain-containing Protein 3) Modulates Fibroblast Growth Factor Signaling during Fast Muscle Development. J Biol Chem. 289(27):18928-42. [PDF]
  • Wei-Yun Lai 賴薇云 (Advisor: Dr. Pan-Cher Yang and Dr. Konan Peck)
    Lai WY, Chen CY, Yang SC, Wu JY, Chang CJ, Yang PC, Peck K. Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme. Molecular Therapy Nucleic Acids (2014) 3, e150. [PDF]
  • Yi-Chih Wu 吳宜之 (Advisor: Dr. Yijuang Chern)
    Wu YC, Lai HL, Chang WC, Lin JT, Liu YJ, Chern Y. (2013) A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. Biochim Biophys Acta. (12):3145-54. [PDF]
  • Yu-Wang Chang 張裕旺 (Advisor: Dr. Chien-Chang Chen)
    Chang YW, Chang YT, Wang Q, Lin JJ, Chen YJ, Chen CC. (2013) Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy. Mol Cell Proteomics. 12(11):3094-107. [PDF]
  • Shao-Chun Hsu 許紹君 (Advisor: Dr. Chien-Chang Chen)
    Hsu SC, Chang YT, Chen CC. (2013) Early growth response 1 is an early signal inducing Cav3.2 T-type calcium channels during cardiac hypertrophy. Cardiovasc Res. 100(2):222-30. [PDF]
  • Cheng-Pu Sun 孫承溥 (Advisor: Dr. Mi-Hua Tao)
    Sun CP, Wu TH, Chen CC, Wu PY, Shih YM, Tsuneyama K, Tao MH. (2013) Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference. Hum Gene Ther. 24(8):739-50. [PDF]
  • Hsiao-Hui Tseng 曾曉慧 (Advisor: Dr. Danny Ling Wang)
    Tseng AH, Shieh SS, Wang DL. (2013) SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic Biol Med. 63:222-34. [PDF]
  • Wei-Chih Yang 楊偉志 (Advisor: Dr. Hsiu-Ming Shih)
    Yang WC and Shih HM. (2013) The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. Oncogene. 32(43):5167-75. [PDF]
  • Wen-Yu Pan 潘玟伃 (Advisor: Dr. Mi-Hua Tao)
    Pan WY, Lo CH, Chen CC, Wu PY, Roffler SR, Shyue SK, Tao MH. (2012) Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains. Mol Ther. 20(5):927-37. [PDF]
  • Chun-Yu Wei 魏淳郁 (Advisor: Dr. Yuan-Tsong Chen and Dr. Shuen-Iu Hung)
    Wei CY, Chung WH, Huang HW, Chen YT, Hung SI. (2012) Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. J Allergy Clin Immunol. 129(6):1562-9. [PDF]
  • Chia-Ching Lin 林家靖 (Advisor: Dr. Chih-Cheng Chen)
    Lin CC, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC. (2012) An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci U S A. 109(2):E76-83. [PDF]
  • Kumar Sanjiv 薩克瑪 (Advisor: Dr. Lee, Te-Chang)
    Sanjiv K, Su TL, Suman S, Kakadiya R, Lai TC, Wang HY, Hsiao M, Lee TC. (2012) The novel DNA alkylating agent BO-1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models. Int J Cancer. 130(6):1440-50. [PDF]
  • Wei-Lun Hwang 黃尉倫 (Advisor: Dr. Hsei-Wei Wang)
    Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, Teng HW, Yang SH, Lan YT, Chiou SH, Wang HW. (2011) SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology. 141(1):279-91. [PDF]
  • Huei-Ying Li 李慧瑛 (Advisor: Dr. Pang-Hsien Tu)
    Li HY, Yeh PA, Chiu HC, Tang CY, Tu BP. (2011) Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation. PLoS One. 6(8):e23075. [PDF]
  • Abd-Al-Ahad nagham George 艾妮荷 (Advisor: Dr. Yuan-Tsong Chen)
    Sabbagha NG, Kao HJ, Yang CF, Huang CC, Lin WD, Tsai FJ, Chen TH, Tarn WY, Wu JY, Chen YT. (2011) Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. Pediatr Res. 70(1):31-6. [PDF]
  • Wen-Hung Chung 鐘文宏 (Advisor: Dr. Yuan-Tsong Chen)
    Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT. (2008) Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med. 14(12):1343-50. [PDF]