Expression of the type I transmembrane glycoprotein CD44 has recently been recognized as a signature for cancer stem cells. In this study, we demonstrate that CD44, once engaged, is internalized and translocated to the nucleus, where it binds to various promoters.
Related Article (J. Cell Biol. 2009 185: 930.)
CD44's nuclear road trip.
EDITORS' CHOICE (Science Signaling)
STAT Signaling: No Phosphate, No Problem.