Dr. Peck, Konan 白果能 博士

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Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses.

The FASEB Journal May 06, 2009

Toll-like receptors (TLRs) play important roles in the immune responses against invading microorganisms. Development of TLR antagonists is recognized as a promising direction in suppressing the associated inflammatory reactions of the TLRs. Aptamers are single-stranded RNA or DNA molecules isolated through an in vitro selection process. Using a novel molecular evolution strategy that combines immunoprecipitation (IP) with systematic evolution of ligands by exponential enrichment (SELEX)

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