Dr. Yan, Yu-Ting 顏裕庭 博士

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Dr. Yan, Yu-Ting
顏裕庭 博士

Associate Research Fellow
副研究員

  • Ph.D., University of Medicine and Dentistry of New Jersey

  • 02-2789-9061 (Lab) (Room No: N616)
  • 02-2652-3941 (Office)
  • 02-2785-8847 (Fax)
  • yyan@ibms.sinica.edu.tw
Specialty:
  • Molecular Genetics
  • Cardiovascular Development 
  • Myofibrillogenesis

RESEARCH

The laboratory studies are on the convergence of extracellular signaling pathways leading to normal and pathophysiological development of the embryonic cardiac and vascular system. The studies primarily utilize experimental approaches involving genetically-engineered mice, but also employ cell culture and biochemical approaches to investigate molecular mechanisms. We are interesting on the cell fate determination, specification and patterning of smooth muscle cells in vascular formation. In particular, we are investigating the functional role of Ankyrin repeat domain-containing protein 17 (ANKRD17) in vascular maturation during embryonic development. In addition, we have identified small heart shock protein B7 (HSPB7) as a biomarker of acute coronary syndrom. Furthermore, we found that loss of HSPB7 result in embryonic lethality. Our recent results suggest that HSPB7 is required  for sarcomerogenesis in heart development. The molecular mechanisms that regulate sarcomere assembly in cardiomyocyte are under investigation now.

研究介紹

本研究室主要探討心臟血管之發育生成以及相關疾病的發生機制。我們建立基因改造小鼠為人類心血管相關疾病模型,探討人類疾病與特定基因之關聯性,以研發並試驗適當之疾病治療方式。目前主要研究方向專注於: (一)胚胎血管系統之發育: 我們專注於胚胎時期血管前趨細胞之生成來源、分化以及血管塑型調節的分子機制之探討。其中發現胚胎發育過程中,失去ANKRD17功能造成胚胎因血管缺陷至死。其生化功能正在進一步探討中。(二)心肌細胞肌小節之生成: 心肌細胞肌小節為心臟肌肉收縮基本單元,任何缺陷發生心肌肌小節生成則造成心肌症、心臟衰竭。已知熱休克蛋白家族在肌小節之生成、修補上扮演重要功能角色。目前我們的研究是以熱休克蛋白HSPB7基因改造小鼠為模型,探討其在肌肉細胞肌小節原生成,心肌症形成所扮演之生物及生化功能角色。

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