Dr. Tao, Mi-Hua 陶秘華 博士

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Dr. Tao, Mi-Hua
陶秘華 博士

Research Fellow
研究員

Specialty:
  • Viral and Cancer Immunology
  • Viral and Cancer Immunotherapy
  • Gene Therapy

RESEARCH

Immunological tolerance is a common feature of chronic viral infections and malignant diseases. The research focus of my laboratory is to understand immunosuppressive mechanisms present in chronic hepatitis B (HBV) infections and in tumor microenvironment, and to develop novel therapeutic strategies to overcome immunosuppression and reactivate virus- and tumor-specific immunity for cure of chronic HBV and HBV-associated hepatocellular carcinoma and other cancers. For HBV studies, we have developed several HBV animal models, including HBV transgenic mice, human liver mice and human immune system mice (generated, respectively, by transplantation of human hepatocytes and/or human hematopoietic stem cells), and HBV pseudoviruses. For cancer immunotherapies, we have developed orthotopic liver cancer model, liver metastasis model of colon cancer, and oncogene-driven spontaneous breast cancer model to evaluate the therapeutic efficacy. Currently, several gene therapy and immunotherapy approaches, including therapeutic vaccines and targeted cytokine delivery, have been applied to treat chronic HBV and liver cancers and other metastatic cancers. Our long-term goal is to develop curative immunotherapies for these important human viral and malignant diseases.

研究介紹

免疫耐受性常見於慢性病毒感染和癌症病人。我們實驗室的研究主題,主要在闡明存在於慢性B型肝炎病毒感染和腫瘤微環境的免疫耐受機制,並研發治療方法,克服免疫耐受性,重新活化病毒和腫瘤的專一性免疫反應,達到清除B型肝炎病毒和肝癌及其他癌症的目的。在B型肝炎病毒研究方面,我們發展了數種動物模式,包括B型肝炎病毒基因轉殖鼠、攜帶人類肝臟和人類免疫系統的擬人化小鼠、以及類B型肝炎病毒顆粒等。在癌症免疫治療方面,我們發展了原位肝癌、大腸癌肝轉移、和致癌基因引發的原發型乳癌等動物模式來評估治療效果。目前,我們應用治療性疫苗和標的傳送細胞激素等基因治療和免疫治療法,來治療慢性B型肝炎和肝癌以及其他轉移癌症我們的最終目標,是發展出可以治癒這些人類重要的病毒和癌症的免疫治療法。

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