Dr. Lin, Wen-chang 林文昌 博士

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Dr. Lin, Wen-chang
林文昌 博士

Research Fellow
研究員

Specialty:
  • Bioinformatics,
  • Tumor Biology
  • MicroRNA Regulation

RESEARCH

The long-term research goal of our laboratory is to utilize bioinformatic tools/databases in elucidating molecular and cellular aspects of functional transcription elements in human genome and their significance in oncogenesis and tumor progression. These functional transcription elements include traditional protein-coding genes and non-coding ones. Our research efforts are intended to elucidate functions and regulations of these transcription elements using bioinformatics data-mining and molecular experimental approaches. Previously, we have used the dbEST database for the discovery of novel human genes, identification of functional nucleotide polymorphisms (SNPs and InDels). Subsequently, we further discover and interrogate a new wobble-splicing mechanism at exon junctions that results in the generation of InDel variants in protein coding transcripts. In order to interrogate the functional aspects of these elements, we have developed gene oriented ortholog assignment and protein domain ortholog classification algorithms and databases. Recently, we have also emphasized on the discovery of non-coding regulatory microRNAs. A new informatics pipeline is employed to discover and interrogate miRNAs from genomic sequences of viruses, parasites and animals. We have now engaged in the regulation features of human miRNAs in development and oncogenesis. It is of our interests to detect serum miRNAs in human cancer patients as possible tumor biomarkers.

研究介紹

本研究室著重於開發生物資訊工具及資料庫,並將研究應用於改善癌症治療策略。除了建立數個人類同源基因研究之生物資訊資料庫應用於功能基因體,進行中計畫包括:microRNA是極小片段的ncRNA,可以調控基因表現。 我們已建立microRNA發掘之生物資訊平台,並對於microRNA基因的轉錄調控進行深入研究。利用序列演化保留的特性,在五十餘個動物基因體中發現超過15000個以上高可信度的新microRNA基因。我們亦開始研究microRNA與人類癌症之關連性及血清中microRNA作為偵測癌症之應用。

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