Dr. Lee, Yungling Leo李永凌 博士

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Dr. Lee, Yungling Leo
李永凌 博士

Associate Research Fellow
長聘副研究員

  • M.D. National Taiwan University

    Ph.D. National Cheng Kung University

  • 02-27899132 (Lab) (Room No: N343)
  • 02-26523013 (Office)
  • 02-27829142 (Fax)
  • leolee@ibms.sinica.edu.tw
Specialty:

1. Clinical Immunology

2. Pharmacogenetics/genomics

RESEARCH

The goal of our laboratory is to investigate genetic regulation, immunological development, prognostic factors and pharmacogenetics in inflammatory diseases. Our current research projects include:

 

1. It is well known that rdT17 cells can express IL-17 enhancing psoriasis progression, because IL-17 stimulates epidermal cells abnormal proliferation and causes a large number of epidermal desquamation. Langerhans cells, a specific subset of dendritic cells, are also related to the cause of psoriasis. Regulatory T cells can promote immune balance and play an important role in suppressing activated T cells. We are interested in the interaction between these immune cells in the skin.

 

2. Keratinocytes provide the physical barrier against outside pathogens, protect the body by producing anti-microbial peptides, and interact with immune cells. We are interested in the intra-cellular signaling pathway of keratinocyte and interactions with immune system, and their relationships with inflammatory skin diseases.

 

3. Taiwanese Consortium of Childhood Asthma Study-inhaled corticosteroid trial (TCCAS-ICS trial) has been established with multiple genomic datasets. We identify differential expressed genes among ICS responders and non-responders, and investigate the predictable genetic signatures and pathways by bioinformatical methods. Neutrophil biomarkers are measured and used to predict ICS response. We also build prediction models based on the validated genetic signatures and biomarkers for ICS response, as well as in independent cohorts. Additionally, we would apply biomarkers into clinical use, and plan to establish asthma personalized therapy strategies by using clinical trial.

研究介紹

本實驗室致力於探索發炎性皮膚病的發生、免疫進展、預後及藥物基因體學,目前我們重點研究的方向有:

 

1. 能表現出IL-17的rdT17細胞已知是造成乾癬(psoriasis)的主因,因IL-17能夠刺激表皮細胞不正常地增厚,造成大量表皮脫屑,在表皮細胞中有一群特化細胞Langerhans cells,對於乾癬的病因具顯著相關。調控性T細胞(regulatory T cells)能促進免疫平衡,對於調節活化的T細胞扮演重要角色,我们對於這些免疫細胞之間的交互作用感興趣。

 

2. 表皮中主要組成的角質細胞(keratinocyte)在結構上能阻隔病源菌、產生抗菌蛋白,還能與免疫細胞作用,我們探討角質細胞的胞內訊息傳遞與免疫系統的交互作用、以及發炎性皮膚病之間的關係。

 

3. 我們建立了Taiwanese Consortium of Childhood Asthma Study-inhaled corticosteroid trial (TCCAS-ICS trial)與全基因體資料庫,透過生物資訊學的方法,尋找和吸入性類固醇藥物反應有關的基因,並藉由生物資訊資料庫探討可能的生物路徑。尋找血清中臨床可用的生物標記,探索嗜中性白血球標記與吸入性類固醇藥物反應之相關性,我們將通過驗證的基因、生物標記,建立可以預測吸入性類固醇藥物反應和長期預後的工具,並以其他獨立族群來驗證預測工具於臨床使用上的實用性。計畫目標是希望利用臨床試驗,驗證生物標記於臨床上預測吸入性類固醇藥物的療效,以達到精準醫療的目的。

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