Dr. Chen, Yuan-Tsong 陳垣崇 博士

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Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.

J Allergy Clin Immunol., Feb 07, 2012

The endogenous peptide-loaded HLA-B∗1502 molecule presented CBZ to CTLs without the involvement of intracellular drug metabolism or antigen processing. The HLA-B∗1502/peptide/β(2)-microglobulin protein complex showed binding affinity toward chemicals sharing 5-carboxamide on the tricyclic ring, as with CBZ. However, modifications of the ring structure of CBZ altered HLA-B∗1502 binding and CTL response.

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