Dr. Shih, Hsiu-Ming 施修明 博士

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Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

J Cell Biol., Jun 21, 2010

Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part via phosphorylating human TACC3 on S558, which triggers TACC3 relocalization to mitotic spindles and stabilizes microtubules (MTs).

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