Dr. Shih, Hsiu-Ming 施修明 博士

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  • Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
    Scientific Reports, Dec 12, 2017
    The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
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  • Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression
    Oncotarget, May 27, 2016
    Long noncoding RNAs (lncRNAs) dysregulated in cancer potentially play oncogenic or tumor-suppressive roles. While the X inactivate-specific ......
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  • HIC1 interacts with and modulates the activity of STAT3.
    Cell Cycle., Jun 21, 2013
    Abstract: HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene, expression of which is frequently suppressed in human cancers. Very ......
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  • Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
    EMBO J., Feb 08, 2013
    While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular sign ......
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  • The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
    Oncogene, Dec 03, 2012
    Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (R ......
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