Dr. Tarn, Woan-Yuh 譚婉玉 博士

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RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing.

JCB., May 02, 2011

Alternative splicing contributes largely to cell differentiation and functional specification. We previously reported that the RNA-binding protein RBM4 antagonizes the activity of splicing factor PTB to modulate muscle cell–specific exon selection of α-tropomyosin. Here we show that down-regulation of PTB and its neuronal analogue nPTB during muscle cell differentiation may involve alternative splicing-coupled nonsense-mediated mRNA decay.

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