Dr. Tarn, Woan-Yuh 譚婉玉 博士

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The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.

Mol Biol Cell., Jan 01, 2013

The exon-junction complex (EJC) deposited on a newly spliced mRNA plays an important role in subsequent mRNA metabolic events. Here we show that an EJC core heterodimer, Y14/Magoh, specifically associates with mRNA-degradation factors, including the mRNA-decapping complex and exoribonucleases, whereas another core factor, eIF4AIII/MLN51, does not.

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