Dr. Tarn, Woan-Yuh 譚婉玉 博士

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DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway.

Oncogene., Jul 21, 2014

The DEAD-box RNA helicase DDX3 is a versatile protein involved in multiple steps of gene expression and various cellular signaling pathways. DDX3 mutations have been implicated in the wingless (Wnt) type of medulloblastoma. We show here that small interfering RNA-mediated DDX3 knockdown in various cell lines increased cell-cell adhesion but decreased cell-extracellular matrix adhesion.

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