Dr. Tarn, Woan-Yuh 譚婉玉 博士

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Alanine repeats influence protein localization in splicing speckles and paraspeckles.

Nucleic Acids Res., Nov 20, 2014

Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities. Alanine-repeat expansion has pathological potential. Here we show that the alanine-repeat tracts influence the subnuclear targeting properties of the RBM4 CAD in cultured human cells.

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