Dr. Chen, Chinpan 陳金榜 博士

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Structural Basis of a Physical Blockage Mechanism for the Interaction of Response Regulator PmrA with Connector Protein PmrD from Klebsiella Pneumoniae.

J Biol Chem., Jul 16, 2013

In bacteria, the two-component system (TCS) is the most prevalent for sensing and transducing environmental signals into the cell. The PmrA-PmrB TCS, responsible for sensing external stimuli of high Fe3+ and mild acidic conditions, can control the genes involved in lipopolysaccharide modification and polymyxin resistance in pathogens. In Klebsiella pneumoniae, the small basic connector protein PmrD protects phospho-PmrA and prolongs the expression of PmrA-activated genes.

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