Dr. Chen, Chinpan 陳金榜 博士



  • Protein–DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA
    Chemical Communications, May 24, 2018
    A new antibacterial drug is urgently needed. We employed a protein–DNA complex-guided pharmacophore modeling approach to screen inhibi ......
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  • Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
    Scientific Reports, Apr 03, 2018
    yclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 ......
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  • In-depth study of DNA binding of Cys2His2 finger domains in testis zinc-finger protein
    PLoS One, Apr 06, 2017
    Abstract   Previously, we identified that both fingers 1 and 2 in the three Cys2His2 zinc-finger domains (TZD) of testis zinc-fin ......
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  • Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
    Nature Comm., Nov 12, 2015
    PmrA, an OmpR/PhoB family response regulator, manages genes for antibiotic resistance. Phosphorylation of OmpR/PhoB response regulator induc ......
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  • Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae.
    Nucl. Acids Res., Dec 25, 2013
    Klebsiella pneumoniae PmrA is a polymyxin-resistance-associated response regulator. The C-terminal effector/DNA-binding domain of PmrA (PmrA ......
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