Dr. Lim, Carmay 林小喬 博士

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A structural-alphabet-based strategy for finding structural motifs across protein families.

Nucleic Acids Res., Jun 04, 2010

Proteins with insignificant sequence and overall structure similarity may still share locally conserved contiguous structural segments; i.e. structural/3D motifs. Most methods for finding 3D motifs require a known motif to search for other similar structures or functionally/structurally crucial residues. Here, without requiring a query motif or essential residues, a fully automated method for discovering 3D motifs of various sizes across protein families with different folds based on a 16-letter structural alphabet is presented.

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