Dr. Lim, Carmay 林小喬 博士

Brand

HIGHLIGHT DETAIL
重要成果詳細內容


Identification of Labile Zn Sites in Drug-Target Proteins.

J Am Chem Soc., Sep 11, 2013

Labile Zn fingers (Zfs) in proteins contain Zn-bound thiolates that can react with electrophilic agents, causing Zn2+ ejection and protein unfolding. Such labile Zfs have been shown to be Cys4 or Cys3His cores whose Zn-bound Cys have no hydrogen bonds. Our aim here is to identify labile Zfs in proteins that are promising drug targets using these features.

Journal Link 期刊連結

List of Highlights
文件紀錄

Top