Dr. Lim, Carmay 林小喬 博士

Brand

HIGHLIGHT DETAIL
重要成果詳細內容


Protein/solvent medium effects on Mg(2+)-carboxylate interactions in metalloenzymes.

J Am Chem Soc, May 12, 2010

We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H (RNase H) from three different organisms. We show that the enzyme can differentiate between different Mg(2+)-binding modes that are nearly equally stable by creating a free-energy barrier between 

Journal Link 期刊連結

List of Highlights
文件紀錄

Top