Dr. Lim, Carmay 林小喬 博士

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  • How the Local Environment of Functional Sites Regulates Protein Function
    Journal of the American Chemical Society, May 19, 2020
    Abstract Proteins form complex biological machineries whose functions in the cell are highly regulated at both the cellular and mol ......
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  • Sensitivity of Functional Loop Conformations on Long-Range Electrostatics: Implications for M20 Loop Dynamics in E. coli Dihydrofolate Reductase
    Journal of Chemical Theory and Computation, Mar 19, 2020
    In E. coli dihydrofolate reductase, unusual conformational motions of a functional M20 loop that interacts with substrate and coenzyme have ......
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  • Why Cellular Di/Triphosphates Preferably Bind Mg2+ and Not Ca2+
    Journal of Chemical Theory and Computation, Nov 27, 2019
    Di/triphosphates perform a multitude of essential tasks, being important components of many vital organic cofactors such as adenosine/guanos ......
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  • Free and Bound Therapeutic Lithium in Brain Signaling
    Accounts of Chemical Research, Sep 26, 2019
    Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......
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  • Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway
    The FASEB Journal, May 07, 2019
    Soluble klotho (sKlotho), the shed ectodomain of α-klotho, protects the heart by down-regulating transient receptor potential canonica ......
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