Dr. Lim, Carmay 林小喬 博士

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  • Why Cellular Di/Triphosphates Preferably Bind Mg2+ and Not Ca2+
    Journal of Chemical Theory and Computation, Nov 27, 2019
    Di/triphosphates perform a multitude of essential tasks, being important components of many vital organic cofactors such as adenosine/guanos ......
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  • Free and Bound Therapeutic Lithium in Brain Signaling
    Accounts of Chemical Research, Sep 26, 2019
    Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......
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  • Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway
    The FASEB Journal, May 07, 2019
    Soluble klotho (sKlotho), the shed ectodomain of α-klotho, protects the heart by down-regulating transient receptor potential canonica ......
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  • How Pb2+ Binds and Modulates Properties of Ca2+-Signaling Proteins
    Inorganic Chemistry, Nov 09, 2018
    Abiogenic lead (Pb2+), present in the environment in elevated levels due to human activities, has detrimental effects on human health. Metal ......
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  • The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair
    Journal of the American Chemical Society (JACS), Oct 08, 2018
    The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8 ......
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