Dr. Lim, Carmay 林小喬 博士

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重要成果


  • Free and Bound Therapeutic Lithium in Brain Signaling
    Accounts of Chemical Research, Sep 26, 2019
    Lithium, a first-line therapy for bipolar disorder, is effective in preventing suicide and new depressive/manic episodes. Yet, how this begu ......
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  • Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway
    The FASEB Journal, May 07, 2019
    Soluble klotho (sKlotho), the shed ectodomain of α-klotho, protects the heart by down-regulating transient receptor potential canonica ......
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  • How Pb2+ Binds and Modulates Properties of Ca2+-Signaling Proteins
    Inorganic Chemistry, Nov 09, 2018
    Abiogenic lead (Pb2+), present in the environment in elevated levels due to human activities, has detrimental effects on human health. Metal ......
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  • The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair
    Journal of the American Chemical Society (JACS), Oct 08, 2018
    The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8 ......
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  • How First Shell–Second Shell Interactions and Metal Substitution Modulate Protein Function
    Inorganic Chemistry, Jun 15, 2018
    Hydrogen bonds to metal–ligands in proteins play a vital role in biological function. They help to stabilize/protect the metal complex ......
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