Dr. Huang, Yi-Shuian 黃怡萱 博士

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Calpain 2 activated through the NMDA receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.

MCB, Jun 18, 2012

Long-term memory requires the activity-dependent reorganization of synaptic proteome to modulate synaptic efficacy and consequently consolidate memory. Activity-regulated RNA translation can change the protein composition at the stimulated synapse. CPEB3 is a sequence-specific RNA-binding protein that represses translation of its target mRNAs in neurons, while activation of NMDA receptors alleviates this repression. Although recent research has revealed the mechanism of CPEB3-inhibited translation, how NMDA receptor signaling modulates the translational activity of CPEB3 remains unclear.

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