Dr. Huang, Yi-Shuian 黃怡萱 博士

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NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.

Nucleic Acids Res., Jun 22, 2012

Cytoplasmic polyadenylation element-binding protein (CPEB)3 is a nucleocytoplasm-shuttling RNA-binding protein and predominantly resides in the cytoplasm where it represses target RNA translation. When translocated into the nucleus, CPEB3 binds to Stat5b and downregulates Stat5b-dependent transcription. In neurons, the activation of N-methyl-d-aspartate receptors (NMDARs) accumulates CPEB3 in the nucleus and redistributes CPEB3 in the

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