Dr. Lee, Eminy H.Y. 李小媛 博士

Brand

HIGHLIGHT DETAIL
重要成果詳細內容


Laminin-β1 Impairs Spatial Learning through Inhibition of ERK/MAPK and SGK1 Signaling.

Neuropsychopharmacology, Aug 17, 2011

Laminin is a major structural element of the basal lamina consisting of an α-chain, a β-chain, and a γ-chain arranged in a cross-like structure, with their C-terminal inter-coiled. Laminin is abundantly expressed in the hippocampus of mature brain and is implicated in several psychiatric disorders, but its possible role involved in learning and memory function is not known. This issue was examined here. Our results revealed that water maze training significantly decreased laminin-β1 (LB1) expression in the rat hippocampal CA1 area.

Journal Link 期刊連結

List of Highlights
文件紀錄

Top