Dr. Lee, Eminy H.Y. 李小媛 博士

Brand

HIGHLIGHT DETAIL
重要成果詳細內容


CREB SUMOylation by the E3 Ligase PIAS1 Enhances Spatial Memory.

J. Neurosci., Jul 16, 2014

cAMP-responsive element binding protein (CREB) phosphorylation and signaling plays an important role in long-term memory formation, but other posttranslational modifications of CREB are less known. Here, we found that CREB1Δ, the short isoform of CREB, could be sumoylated by the small ubiquitin-like modifier (SUMO) E3 ligase protein inhibitor of activated STAT1 (PIAS1) at Lys271 and Lys290 and PIAS1 SUMOylation of CREB1Δ increased the expression level of CREB1Δ.

Journal Link 期刊連結

List of Highlights
文件紀錄

Top