Dr. Lin, Teng-Nan 林天南 博士

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Novel Link of Anti-apoptotic ATF3 with Pro-apoptotic CTMP in the Ischemic Brain.

Mol Neurobiol., Apr 26, 2014

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor with diverse functions under disease states in multiple cell types. ATF3 has neuroprotective action against cerebral ischemia, which may involve caspase 3. However, the molecular mechanisms underlying ATF3 regulation of apoptosis are largely unknown. Here, we used gain- and loss-of-function and rescue approaches to demonstrate ATF3 attenuating hypoxic neuronal apoptosis.

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