Dr. Shieh, Sheau-Yann 謝小燕 博士

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Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.

J Biol Chem., Apr 24, 2014

Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its importance in safeguarding proper chromosome segregation, how hMps1 is recruited to the kinetochore remains incompletely understood. Here we demonstrate that phosphorylation at threonine 288 (T288) by the cell cycle checkpoint kinase CHK2 is involved in this process.

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